Damp Diagnosis

Mould, damp and the lungs

DAMP signaling in fungal infections and diseases

Fungal infections and diseases predominantly affect patients with deregulated immunity. Compelling experimental and clinical evidence indicate that severe fungal diseases belong to the spectrum of fungus-related inflammatory diseases. Some degree of inflammation is required for protection during the transitional response occurring temporally between the rapid innate and slower adaptive response...

Occupational rhinitis in damp and moldy workplaces.

BACKGROUND Numerous studies confirm the association between exposure to indoor air dampness and molds and different health outcomes. Of these, upper respiratory tract problems are the most commonly reported work-related symptoms in damp indoor environments. The aim of this study was to describe a clinically investigated patient series with occupational rhinitis induced by molds. METHODS Nasal...

Rage mediated DAMP signaling in intestinal tumorigenesis

In the intestine, a large variety of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) can instigate innate immune responses, which have been shown to promote colorectal carcinogenesis. We have recently demonstrated an important role for the receptor for advanced glycation end products (Rage) in intestinal adenoma formation. Rage is a receptor for D...

Crystal structure of the NurA–dAMP–Mn complex

Generation of the 30 overhang is a critical event during homologous recombination (HR) repair of DNA double strand breaks. A 50–30 nuclease, NurA, plays an important role in generating 30 singlestranded DNA during archaeal HR, together with Mre11–Rad50 and HerA. We have determined the crystal structures of apoand dAMP-Mn-bound NurA from Pyrococcus furiousus (Pf NurA) to provide the basis for it...